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Documentation
A Certificate of Analysis is the most critical quality document for research peptides. It documents the results of independent laboratory analyses — and is the only reliable proof that a compound is what it is claimed to be.
A Certificate of Analysis (CoA) is a document that records the results of an analytical test of a substance. In the context of research peptides, the CoA typically documents the purity, identity, and other analytical parameters of a specific production batch.
Crucially, a CoA is only meaningful if it has been issued by an independent, accredited third-party laboratory — not by the manufacturer themselves. A self-issued CoA has no independent evidentiary value.
A complete CoA for a research peptide typically contains the following information:
Important
A CoA is always batch-specific. It applies exclusively to the analyzed batch — not to all of a provider's products. A CoA issued once provides no information about subsequent batches.
The purity value in the CoA — typically expressed as a percentage such as "≥98%" — indicates what proportion of the measured substance is accounted for by the target compound. In an HPLC-UV analysis, the peak area of the target compound is calculated in relation to the total peak area.
What does this mean in practice?
There is no regulatory mandate for independent quality testing in the research peptide market. This means: without a CoA from an independent laboratory, there is no verified proof of a compound's purity or identity.
However, batch quality is crucial for the reproducibility of research results. Variations in purity or impurities can significantly influence outcomes in cell culture and preclinical models.
A batch-specific CoA from an accredited third-party laboratory is therefore not just a quality feature — it is a fundamental prerequisite for scientifically robust research with synthetic peptides.
Pepwerk publishes a batch-specific CoA for every released batch — issued by an independent accredited laboratory in Germany. The documents are publicly accessible in the CoA library and contain HPLC-UV purity values as well as mass spectrometry confirmation of molecular identity.
Batches that do not meet our minimum purity of ≥98% are not released and not sold.
Note
This article is for scientific information purposes only. It does not constitute medical advice. All mentioned products are intended exclusively for research purposes in authorized laboratory environments.
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