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Fundamentals
Lyophilization is the standard procedure for the preservation of research peptides. The process, the benefits for stability and shelf life — and what this means for correct storage.
Lyophilization — also known as freeze-drying — is a gentle drying process in which water is removed from a frozen sample through sublimation. This means: the water transitions directly from the solid state (ice) to the gaseous state without passing through the liquid state.
The process occurs in three phases: freezing of the sample, primary drying (sublimation of free water under vacuum), and secondary drying (removal of bound residual water). The result is a dry, porous powder — the lyophilized solid.
Synthetic peptides are susceptible to hydrolysis, oxidation, and microbial growth in aqueous solution. Lyophilization removes water as a reaction medium, drastically slowing down chemical degradation processes.
The advantages compared to liquid formulations:
Important
Lyophilized peptides should be stored at −20°C, protected from light and dry. After opening the vial and after reconstitution, different storage conditions apply — use reconstituted solutions at 4°C and promptly.
The following recommendations apply for the optimal stability of lyophilized peptides:
Reconstitution refers to the dissolution of the lyophilized powder in a solvent prior to use in a research context. For research peptides, bacteriostatic water (0.9% benzyl alcohol) or sterile water is typically used.
Bacteriostatic water has the advantage that the benzyl alcohol acts as a preservative and makes the reconstituted solution suitable for multiple withdrawals — in contrast to sterile water without preservatives.
Note
This article is for scientific information purposes only. It does not constitute medical advice. All products mentioned are intended exclusively for research purposes in authorized laboratory environments.